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First-line tandem high-dose chemotherapy and autologous stem cell transplantation versus single high-dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies

A APM apoia a Campanha Março Borgonha, de conscientização sobre o Mieloma Múltiplo, tipo de câncer desconhecido por grande parte da sociedade médica. Embora a prevalência seja maior em idosos, jovens também podem desenvolver a doença. Durante o mês, divulgaremos informações e entrevistas com especialistas em nossas mídias sociais. Acesse o site da campanha e acompanhe nossos canais!

Frauke Naumann-Winter, Alexander Greb, Peter Borchmann, Julia Bohlius, Andreas Engert, Roland Schnell

Background

Several clinical studies have compared single with tandem (also called double) autologous stem cell transplantation (ASCT) as first-line treatment in patients with symptomatic multiple myeloma (MM), one of the leading indications for ASCT worldwide.

Objectives

The present Cochrane Review compares tandem autologous stem celltransplantation (TASCT) with single autologous stem celltransplantation (SASCT) as first-line treatmentin patients with symptomatic MM with respectto overall survival (OS), event-free survival (EFS), quality of life (QoL) and treatment- or transplantation-related mortality.

Search methods

We systematically identified controlled trials published between January 1995 and May 2011 in two bibliographic databases (MEDLINE and CENTRAL) and in clinical trial registries.

Selection criteria

One researcher screened references for controlled trials to determine eligibility for the systematic review (SR) according to pre-specified inclusion and exclusion criteria, reflecting characteristics of disease and the interventions. We required a minimal set of details to be reported for observational studies for the studies to be included.

Data collection and analysis

We critically evaluated eligible trials with respect to quality of design and actual performance. One researcher extracted individual trial results, which were checked by another researcher. We recapitulated the results of the individual trials in a standardised way for the SR in order to allow a systematic assessment of potential sources of bias.

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